Dr. Adi Aran

Dr. Adi Aran

Director of the Neuro-pediatric unit ,Shaare Zedek Medical Center Jerusalem


Hebrew University-Hadassah Medical School, Jerusalem, Israel MD 1999 Medicine
Hebrew University-Hadassah Medical School, Jerusalem, Israel M.Sc 1998 Biochemistry
Department of Psychiatry, Stanford Univ. CA. Host: Emmanuel Mignot, MD,PhD Post-Doctoral Fellowship 2009 Sleep Disorders

Research and professional experience:
Clinical position

2016 – Director. Pediatric Neurology and Developmental Medicine, Shaare Zedek Medical Center, Jerusalem, Israel

Professional experience/personal statement
My research projects over the past years combine basic science with bedside clinical observations, most recently researching the genetic basis of familial microcephaly in a local cohort and uncovering the affected protein and its function. A similar project has recently been concluded on congenital pre-synaptic myasthenia gravis. I have also focused efforts on understanding the therapeutic effects of CBD-based medical cannabis in neurocognitive disorders, including ASD. The dramatic clinical effect seen in some cases has led me to further explore the potential benefits, and possible risks, of cannabinoids, particularly in children. I have initiated studies exploring the effects of medical cannabis in epilepsy and ASD. I am a consultant to the Ministry of Health for medical cannabis, indications and use in children and spend much time educating physicians and lay audiences on this topic.

Selected publications
Aran A PI, Shalev RS C, Biran G C, Gross-Tsur V C. (2007). Parenting style impacts on quality of life in children with cerebral palsy. J Pediatrics. 151 (1): 56-60, 60.el.
Aran A PI; Nevsimalova S C; Plazzi G C; Hong SC C; Weiner K C; Zeitser J C; Mignot E PI. (2009). Elevated anti-streptococcal antibodies in patients with recent narcolepsy onset. SLEEP. 32(8):979-983.
Aran A PI; Einen M T; Lin L C; Plazzi G C; Nishino S C; Mignot E PI.(2010). Clinical and therapeutic aspects of childhood narcolepsy-cataplexy: a retrospective study of 51 children. SLEEP; 33(11):1457-1464.
Aran A PI, Weiner K C, Lin L C, Finn LA C, Greco MA C, Peppard P C, Young T C, Ofran Y C, Mignot E PI. (2010). Post-Streptococcal Auto-Antibodies Inhibit Protein Disulfide Isomerase and Are Associated with Insulin Resistance. PLoS ONE ;5(9):e12875.
Aran A PI, Lin L C, Finn LA C, Weiner K C, Peppard P C, Young T C, Mignot E C. (2011) Post-Streptococcal antibodies are associated with metabolic syndrome in a population-based sample of healthy adults. PLoS ONE. 2011;6(9):e25017.
Aran A PI, Shors I C, Lin L C, Mignot E C, Schimmel M C. (2012). CSF Levels of Hypocretin-1 (Orexin-A) Peak during Early Infancy in Humans: SLEEP 1:35(2): 187-91.
Aran A PI , Vasertile N C , Gross I C,  Mendelevitch Y C  and Polak Y C .  (2016) Medical decisions of pediatric residents turn riskier after a 24-hour call with no sleep. Med Decis Making. [Epub ahead of print] (IF-3.24, 4/24)
Aran A PI, Rosenfeld N C, Jaron R C, Renbaum P C, Zuckerman S C, Fridman H C, Zeligson S C, Segel R C, Kohn Y C, Kamal L C, Kanaan M C, Segev Y C, Mazaki E C, Rabinowitz R C, Shen O C, Lee M C, Walsh T C, King MC C, Suleyman G C and Levy-Lahad E PI.(2016). Loss-of-function of PCDH12 underlies recessive microcephaly mimicking intrauterine infection. Neurology. 86(21):2016-24.
Aran A PI , Segel R C , Kaneshige K C, Gulsuner S C, Renbaum P C , Oliphant S C, Meirson T C, Weinberg-Shukron A C, Hershko Y C , Lee M.K C., Samson A.O. C, Parsons S C, King M.C. C, ,Levy-Lahad E PI, , Walsh T. C, (2016). Vesicular acetylcholine transporter defect underlies devastating congenital myasthenia syndrome. Neurology, accepted, in production